RT Journal Article SR Electronic T1 C-reactive protein (CRP) as a marker of disease severity in community acquired pneumonia patients with sepsis JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P1992 VO 40 IS Suppl 56 A1 Saicharan Bodi A1 Himayatullah Khan A1 Dinesh Babu A1 Vivek Gupta A1 Ajith Raghavan A1 A. Pramod A1 HARI YR 2012 UL http://erj.ersjournals.com/content/40/Suppl_56/P1992.abstract AB INTRODUCTION: C - Reactive Protein (CRP), an early sensitive marker of inflammation is studied extensively in various common medical disorders.Until recently CRP measurement was not studied widely in Pneumonias .We intended to study its usefulness for assessment of disease severity in patients of Community acquired pneumonia (CAP) with Sepsis.OBJECTIVE: To evaluate the utility of C - Reactive Protein as a marker of disease severity in patients of Community acquired pneumonia with Sepsis.METHODS:Study design: Prospective observational study.Setting: 12 bedded ICU of a multi speciality hospital in Abudhabi, UAE.Subjects: 40 patients admitted during June 2010 - January 2012, fulfilled the study criteria.CAP and Sepsis were defined based on the ATS and ACCP/SCCM 1992 criteria respectively.RESULTS: Patients were divided into two groups, Group A with CRP < 300 mg/ L and Group B with > 300 mg/ L with mean age being 36.5 and 42.6 years respectively. Characteristics of disease severity were compared in both the groups.View this table:Table1.Disease severityPresentation of septic shock, severe sepsis and multiorgan dysfunction was significantly higher in group B (p< 0.05).Mean CRP value among nonsurvivors was 355.33 mg/ L and 257.56 mg/L among survivors (p <0.05).CONCLUSION: CRP value of greater than 300 mg / L within first 48 hours of admission in ICU appears to be a good marker of disease severity in patients of Community acquired pneumonia with Sepsis and may be useful to identify high risk patients.