RT Journal Article SR Electronic T1 The influence of smoking on the level of proinflammatory cytokines in patients with COPD JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P1062 VO 40 IS Suppl 56 A1 Liubov Dolinina A1 Vasilii Trofimov A1 Anna Delieva A1 Olga Galkina YR 2012 UL http://erj.ersjournals.com/content/40/Suppl_56/P1062.abstract AB Smoking is a major risk factor for COPD. The mechanisms of the effect of smoking on the progression of the disease is not fully understood.The purpose of: To identify the relationship of smoking and the activity of local and systemic inflammation in patients with COPD.A total of 98 patients, 76 of them smokers with an average experience of smoking a pack of 25 ± 1,8 / year. Revealed that smokers C-reactive protein blood (12,7 ± 4, 5 mg / L), TNFα from bronchial washings (6,3 ± 1,9 pkg / ml) and TNFα from serum (12,19 ± 4, 0 pkg / ml) significantly (p <0,005) higher than in nonsmokers (3,15 ± 0,94 mg / L, 2,15 ± 1,8 pkg / ml, 8,57 ± 4,03 pkg / ml respectively). At the same time in smoking patients was significantly greater neutrophils in sputum and sputum IL-8. There were significant (p <0,005) negative correlation between the level of IL-8 in sputum, and FEV1 (r = 0,363).Conclusion. The study allowed to identify and confirm the relationship of smoking to the presence and activity of inflammatory process local and systemic in patients with COPD.