TY - JOUR T1 - Home mechanical ventilation and respiratory rehabilitation: Influence in BODE index, quality of live and inflammatory parameters JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P1711 AU - Eduardo Marquez-Martin AU - Pilar Cejudo AU - Jose Luis Lopez-Campos AU - Ana Rodriguez AU - Borja Valencia AU - Emilia Barrot AU - Francisco Ortega Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P1711.abstract N2 - Our aim is to assess the impact on BODE index, quality of live and inflammatory parameters (IP) of a respiratory rehabilitation program (RR) compared with a program of home mechanical ventilation (HMV) and the summation of both interventions. Methods: 45 COPD patients with severe functional impairment and in situations of hypercapnic respiratory failure were prospectively randomized to 3 groups: RR (12 weeks in 40-minute sessions that included strength training and resistance), HMV (12 weeks BiPAP mode) and RR-HMV (combination of the two interventions). The patients underwent diferents components of BODE index, quality of live (CRDQ) and IP: C Reactive Protein (CRP), Tumor Necrosis Factor-α (TNF-α), Interleucin-6 (IL-6), IL-8 and Surfanctan D Protein (SDP). Results: HMV group improved BODE index significantly by decreasing median 2 points (p = 0.003). Also get statistically significant improvement in quality of life index CRDQ (in total and its four components). IP improved significantly by decreasing TNF-α and IL-8. RR group obtained the same results in BODE index, and CRDQ. IP significantly improved by lowering CRP, IL-8, SDP and C3. RR-HMV group improves BODE index significantly when going from 5 to 3.5 (p = 0.001). CRDQ in total and components of dyspnea, fatigue and disease control. Significantly improved IP by lowering CRP, TNF-α, SDP and prealbumin. Conclusions: HMV and the RR produced improvement in the BODE index and quality of life as well as when the two interventions are given together without finding differences when applied independently. The combination of both intervention control more IP than each other separately. ER -