RT Journal Article
SR Electronic
T1 Resting energy expenditure in patients with obstructive sleep apnea
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P1884
VO 40
IS Suppl 56
A1 Miroslav Brusik
A1 Radovan Tisko
A1 Zuzana Sopkova
A1 Ruzena Tkacova
A1 Pavol Joppa
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P1884.abstract
AB Introduction: Obstructive sleep apnea (OSA) may contribute to increases in resting energy expenditure (REE) through hypoxia-related sympathetic activation and hormonal dysregulation. The reports on REE in OSA are scarce, and are confounded by body weight and gender differences.Aim: We assessed REE adjusted for fat-free mass (FFM) in male patients with OSA and hypothesized that REE/FFM ratio is related to indices of OSA severity.Methods: 26 male subjects (age 48.4±11.3 years) evaluated for suspected OSA underwent overnight polysomnography. Body composition was assessed by tetrapolar bioimpedance method and REE by indirect calorimetry. REE/FFM ratio was compared between 16 patients with severe OSA [apnea-hypopnea index (AHI)>30; mean AHI 60.8±20.1 events/hour] and 10 control subjects (AHI<15; mean AHI 10.7±4.4).Results: Patients with severe OSA had increased REE/FFM compared to controls (30.4±3.1 versus 27.3±4.0 kcal/kg/24 h, p=0.033). In univariate analyses, REE/FFM was directly related to AHI, oxygen desaturation index (ODI) and arousal index (R=0.486, p=0.012; R=0.561, p=0.003; R=0.482, p=0.013, respectively). In multivariate analysis, only ODI remained an independent predictor of REE/FFM after adjustments for age, body mass index, AHI and arousal index (p=0.027, R2=0.438).Conclusion: Resting metabolic rate was increased in patients with severe OSA and correlated with indices of OSA severity. The independent predictive value of ODI suggests a possible role for intermittent hypoxia in the regulation of energy metabolism in OSA.Support: APVV-0134/11, VEGA 1/0111/12, 8/GSD/2011, Slovakia.