RT Journal Article
SR Electronic
T1 Endothelial damage markers in patients with pandemic influenza A (H1N1/09)
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2544
VO 40
IS Suppl 56
A1 Sergei Lukyanov
A1 Anatoly Govorin
A1 Vladimir Gorbunov
A1 Elena Romanova
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P2544.abstract
AB Introduction. One of the most important features of influenza A (H1N1) is endothelium damage. In patients with lethal outcomes because of A (H1N1) antigens of a virus in endotheliocytes of pulmonary capillaries were founded (Shieh, W.J. et al. Am. J. Pathol. 2010 177:167-175). Aims and objectives. The aim of the study is to define the value of endothelial damage markers in patients with influenza A (H1N1) in the course of the disease and its outcomes. Methods. 135 patients with pneumonia associated with influenza A (H1N1) during pandemy'2009 were examined in Chita. Of them 58 (group I) were hospitalized to the intensive care units. Group II included 77 patients in the pulmonological department. The virus was verified by the polymerase chain reaction. Plasma level of desquamated endotheliocytes (DEC) and intercellular adhesion molecule-1 (sICAM-1) was determined in all patients, using enzyme-linked immunosorbent assay and immunohistochemistry. For statistical analysis, Mann-Whitney test was applied. Significance was assumed if p value was 0.05. Results. In 44 patients acute respiratory distress-syndrome or acute lung injury (ARDS/ALI) was diagnosed, 20 patients died. The level of DEC and sICAM-1 was elevated in patients of I group - 16 [12,5; 18] and 415 [238; 552] against 8 [6; 10,5] and 219 [179; 338] in group II (p<0.001). The level of DEC and sICAM-1 was considerably raised in patients with ARDS/ALI: 18,5 [16,5; 21] and 525 [372; 672] accordingly. The relative risk of lethal outcome in those patients was 24,4 [3,3; 177]. Conclusion. The high level of DEC and sICAM-1 is associated with severe course of influenza A (H1N1), also with the development of ARDS/ALI and lethal outcomes of the disease.