PT  - JOURNAL ARTICLE
AU  - Roger Fei Falkenstern-Ge
AU  - Markus Wohlleber
AU  - Martin Kimmich
AU  - Sabine Bode-Erdmann
AU  - German Ott
AU  - Martin Kohlhäufl
TI  - Late lung metastasis of endometrial cancer. Two rare cases of patients with late lung metastasis of primary endometrial cancer 14 and 17 years after initial treatment
DP  - 2012 Sep 01
TA  - European Respiratory Journal
PG  - P1250
VI  - 40
IP  - Suppl 56
4099  - http://erj.ersjournals.com/content/40/Suppl_56/P1250.short
4100  - http://erj.ersjournals.com/content/40/Suppl_56/P1250.full
SO  - Eur Respir J2012 Sep 01; 40
AB  - IntroductionThe longest interval of lung metastasis from endometrial cancer was initially reported 17 years after standard surgical treatment.Aims and objectivesNearly 80% of all recurrences of endometrial cancer occur within 3 years after the initial treatment. We report two cases of lung metastasis 14 and 17 years after the initial surgical treatment of endometrial cancer.MethodsA 71- year-old female was referred to our center for histological diagnosis of lung lesions. Histological biopsy showed lung metastasis of an endometrial cancer which was resected 17 years ago.A 77- year-old female was also referred for histological diagnosis of multiple lung lesions and a clavicle metastasis. Both clavicle and lung biopsy revealed metastasis of an endometrial cancer treated 14 years ago surgically.ResultsOur first patient was treated with organ- preserving metastatic wedge resection. The latency period in the first case between initial treatment of endometrial cancer and pulmonary metastases was 17 years. Our second patient with widespread metastasis was treated with palliative radiotherapy and systemic chemotherapy. The latency period between initial diagnosis and treatment of endometrial cancer and pulmonary metastases in the second case was 14 years.ConclusionLung metastases originating from tumors of the female genital tract are very rare. We report of lung metastasis from endometrial cancer with a latency period of 14 and 17 years. To our knowledge, in the literature there is only one case reported with a similar extreme latency.