PT  - JOURNAL ARTICLE
AU  - Claudia Oshiro
AU  - Diogo Kogiso
AU  - Beatriz Romanholo
AU  - Lourdes Martins
AU  - Alfesio Braga
AU  - Paulo Saldiva
AU  - Maria Garcia
TI  - Exhaled nitric oxide in traffic professionals exposed to ambient urban air pollution
DP  - 2012 Sep 01
TA  - European Respiratory Journal
PG  - P1033
VI  - 40
IP  - Suppl 56
4099  - http://erj.ersjournals.com/content/40/Suppl_56/P1033.short
4100  - http://erj.ersjournals.com/content/40/Suppl_56/P1033.full
SO  - Eur Respir J2012 Sep 01; 40
AB  - Exhaled nitric oxide (eNO) has been used as a non-invasive method to assess lung inflammation. Urban air pollution is associated with inflammatory markers and increased risk of pulmonary diseases. Traffic professionals are at risk of vehicular pollution exposure. However few studies have been published testing eNO in this group. We aim to study the association between air pollution, blood inflammatory markers and eNO in traffic professionals of Sao Paulo city (SP). Non smokers cab drivers (N=46) and traffic controllers (N=23) of SP were evaluated 4 times after work shifts. Pollutants (PM2.5 measured by reflectance and NO2 by colorimetry) were collected by individual samplers during 24h exposure before each evaluation. eNO, ultra sensitive C- Reactive Protein (us-CRP) and Erythrocyte Sedimentation Rate (ESR) were measured by ozone-chemiluminescence, high pressure liquid chromatography, nephelometry respectively. Inflammatory markers data were tested against pollutants levels by Linear regression model for repeated measures through generalized estimated equations (LME GEE). Statistical significance was set at 10%. PM2.5 was 40.33±20.83ug/m3 and NO2 197.25±43.47 ppm. eNO was 23.28±16.72 ppb, us-CRP 5.28±6.07 mg/L and ESR 3.21±3.20 mm/h. After adjustment for cardiovascular risks (abdominal circumference, hypertension, diabetes, age, body mass index) GEE tests showed associations between eNO and ambient NO2 (p<0.10) and us-CRP (p<0.05, adjusted for ESR and NO2). PM2.5 was correlated to both inflammatory blood markers (ESR p<0.05 and us-CPR p<0.10). We conclude that eNO is an inflammatory marker of deleterious lung effects of ambient air pollution in traffic professionals from SP.