RT Journal Article
SR Electronic
T1 Adipokines in obese children and adolescents with sleep-disordered breathing
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 4310
VO 40
IS Suppl 56
A1 Kim Van Hoorenbeeck
A1 Hilde Franckx
A1 Patrick Debode
A1 Luc Van Gaal
A1 Kristine Desager
A1 Wilfried De Backer
A1 Stijn Verhulst
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/4310.abstract
AB Background: Sleep-disordered breathing (SDB) is prevalent in obesity. It has been linked to the metabolic syndrome. Possible mechanism is intermittent hypoxia of the fat tissue and alterations of adipokine secretion.Aim: This study looked into the effects of intermittent hypoxia on adipokine levels before and after weight loss treatment.Methods: Obese children and adolescents between 10-18 years were included while entering an inpatient weight loss treatment program. All patients had 2 visits: baseline and after 4-6 months of treatment. Leptin, adiponectin, TNF-alpha and IL-6 were determined at both visits and a sleep screening was performed at baseline and repeated in case of SDB.Results: 158 patients participated in this study. Median age was 15.7 years (10.9-18.0). Mean BMI z-score was 2.75+/-0.42. 26% of participants had SDB at baseline. Mean nocturnal saturation correlated with leptin (r=0.19; P=0.02) and adiponectin (r=-0.17; P=0.04). IL-6 correlated with oxygen desaturation index (r=-0.20; P=0.02). TNF-alpha levels were not linked to sleep parameters. After weight loss 19% of subjects with SDB at baseline that participated in the follow-up study had residual SDB. Average weight loss was 29%. Correlation analysis did not show associations between improvements in sleep parameters and improvements in adipokines. These were mostly linked to a lowering in BMI z-score.Conclusion: In an obese pediatric population SDB was linked to changes in the secretion profile of leptin, adiponectin and IL-6. After weight loss treatment levels of leptine, adiponectin, IL-6 and TNF-alpha did not improve in association with improvements in sleep parameters.