PT  - JOURNAL ARTICLE
AU  - Kim Van Hoorenbeeck
AU  - Hilde Franckx
AU  - Patrick Debode
AU  - Luc Van Gaal
AU  - Kristine Desager
AU  - Wilfried De Backer
AU  - Stijn Verhulst
TI  - Adipokines in obese children and adolescents with sleep-disordered breathing
DP  - 2012 Sep 01
TA  - European Respiratory Journal
PG  - 4310
VI  - 40
IP  - Suppl 56
4099  - http://erj.ersjournals.com/content/40/Suppl_56/4310.short
4100  - http://erj.ersjournals.com/content/40/Suppl_56/4310.full
SO  - Eur Respir J2012 Sep 01; 40
AB  - Background: Sleep-disordered breathing (SDB) is prevalent in obesity. It has been linked to the metabolic syndrome. Possible mechanism is intermittent hypoxia of the fat tissue and alterations of adipokine secretion.Aim: This study looked into the effects of intermittent hypoxia on adipokine levels before and after weight loss treatment.Methods: Obese children and adolescents between 10-18 years were included while entering an inpatient weight loss treatment program. All patients had 2 visits: baseline and after 4-6 months of treatment. Leptin, adiponectin, TNF-alpha and IL-6 were determined at both visits and a sleep screening was performed at baseline and repeated in case of SDB.Results: 158 patients participated in this study. Median age was 15.7 years (10.9-18.0). Mean BMI z-score was 2.75+/-0.42. 26% of participants had SDB at baseline. Mean nocturnal saturation correlated with leptin (r=0.19; P=0.02) and adiponectin (r=-0.17; P=0.04). IL-6 correlated with oxygen desaturation index (r=-0.20; P=0.02). TNF-alpha levels were not linked to sleep parameters. After weight loss 19% of subjects with SDB at baseline that participated in the follow-up study had residual SDB. Average weight loss was 29%. Correlation analysis did not show associations between improvements in sleep parameters and improvements in adipokines. These were mostly linked to a lowering in BMI z-score.Conclusion: In an obese pediatric population SDB was linked to changes in the secretion profile of leptin, adiponectin and IL-6. After weight loss treatment levels of leptine, adiponectin, IL-6 and TNF-alpha did not improve in association with improvements in sleep parameters.