TY - JOUR T1 - Paradoxical effect of salbutamol in asthmatic children JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P4575 AU - Maria Teresa Romero Rubio AU - Lysbet Ojeda Gonzalez AU - Barbara Fernandez Dominguez AU - Laura Aranda Grau AU - Amparo Escribano Montaner Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P4575.abstract N2 - Paradoxical bronchospasm is defined as the rapid onset of bronchoconstriction after administrating β2 agonist. Few studies published suggest that it is due to tensiactive chlorofluorocarbons in the metered dosis inhaler (MDI). Although bronchodilator test (BT) with salbutamol is a usual aim of control in asthma, there are no studies in these children.Objective: To set the characteristics of paradoxical bronchospasm after standard BT with MDI salbutamol in asthmatic children.Methods: Asthmatic children (2006-2011) in whom FEV1 decreases ≥9 % after conventional BT with MDI salbutamol.Age,sex,body mass index,atopy,pharmacological treatment,level of asthma severity and control,percentage of FEV1 decrease and brochodilator response after terbutaline dry powder were collected. Statistical analysis with SPSS.Results: 32 patients,mean age 8.3 years (56% males).History of allergy in 65.6% (68.4% Dermatophagoides) and obesity in 34.3%. 81.3% patients had controlled asthma at the time of testing,following treatment with montelukast (42.9%),inhaled corticosteroids (28.5%),both of them (4.8%) or immunotherapy (9.5%). 14.3% patients had moderate to severe asthma, treated with corticosteroids and long acting beta-agonist. 46.9% showed a fall in FEV1 >15%. In this group 40% were obese and 60% allergic, with no differences among asthma severity or pharmacological therapy (p>0.05). 27 patients underwent bronchodilation with terbutaline dry powder being positive in 81%.Conclusion: In controlled asthmatic children, especially obese and allergic,MDI salbutamol can produce paradoxical bronchoconstriction that reverts with terbutaline drypowder. Although not a usual situation, it should be considered for the symptomatic management of the disease. ER -