PT - JOURNAL ARTICLE AU - Maria Lucia Bueno Garcia AU - Lourdes Conceição Martins AU - Alfesio Braga AU - Miriam Lemos AU - Luis Pereira AU - Paulo Afonso AU - Paulo Saldiva AU - Paula Santos Ubiratan TI - Inflammation in traffic professional from Sao Paulo after pollutants emission control implementation DP - 2012 Sep 01 TA - European Respiratory Journal PG - P3996 VI - 40 IP - Suppl 56 4099 - http://erj.ersjournals.com/content/40/Suppl_56/P3996.short 4100 - http://erj.ersjournals.com/content/40/Suppl_56/P3996.full SO - Eur Respir J2012 Sep 01; 40 AB - In the last decade, ambient particles have decreased from 150ug/m3 to 40ug/m3 in São Paulo city (SP) because of public policies to control fuel emissions Traffic professional are more exposed to air pollution. We tested if ambient air from SP is still deleterious to traffic professionals. Non or ex-smokers (≥1 year) cab drivers (N=46) and traffic controllers (N=23) were evaluated 4 times. We checked clinical symptoms and blood inflammatory markers (HDL/LDL/total cholesterol, triglycerides, blood cell counting, clot tests, ultra sensitive c reactive protein- us CRP and erythrocyte sedimentation rate-ESR) on the day after workshift. Pollutants were collected during 24h exposure by individual samplers for fine particles (reflectance) and NO2(colorimetry). Clinical and blood data were tested against pollutants by linear regression model for repeated measures through generalized estimated equation (GEE). Alpha was 5%. PM2.5 was 40,33±20.83ug/m3 and NO2 197±43,47ugm3. Traffic professional referred cough (19%), coryza (21,4%), sneezing (35,6%), nasal stuffiness (34,5%)and itch(28,6%), rhinitis (35,6%), wheezing (14,3%), dyspnea (10,7%) which improved during non working periods (60,7%)(holidays or weekends). ESR, clot tests (prothrombin INR, activated partial thromboplastin time and thromboplastin time), LDL chol and mononuclear cells in blood were associated to both PM2.5 (p<0.05). There was no correlation of usCRP to inflammation and fibrinogen to pollutants. We conclude that urban pollutants exposure in SP city is still associated with clinical upper respiratory, vascular and systemic inflammation, hypercoagulability and lymphocytes and monocytes increment in traffic professional.