TY - JOUR T1 - Correlation of pulmonary function and sleep disordered breathing parameters in patients with idiopathic pulmonary fibrosis JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P894 AU - Charalampos Mermigkis AU - Izolde Bouloukaki AU - Katerina Antoniou AU - Giannis Giannarakis AU - Helen Mauroudi AU - Violeta Moniaki AU - Nikolaos Siafakas AU - Sophia Schiza Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P894.abstract N2 - Background: Restrictive pulmonary diseases like Idiopathic Pulmonary Fibrosis (IPF) are characterized by decreased lung volumes that can reduce the upper airway stability and potentially predispose to SDB.Aims and objectives: Therefore our aim was to correlate pulmonary function testing (PFT) parameters with Apnea-Hypopnea Indices (AHI), overall and during NREM and REM sleep, in newly diagnosed IPF patients.Methods: Twenty consequent patients (16 males/4 females, age 68.5± 11 yrs) with newly diagnosed IPF were included. All had a formal in lab sleep study as well as PFT's before the initiation of any therapy for IPF.Results: Twelve patients had an AHI above 5 per hour of sleep indicating underlying SDB. A statistical significant trend was observed between RV and RV/TLC values and REM AHI (p=0.07, r=-0.44 and p=0.08, r=-0.43 respectively). No statistical significant correlations were observed between the other PFT parameters (FEV1%, FVC%, FEV1/FVC, TLC, VC) and AHI indices. DLCO/VA values showed a statistical significant negative correlation with overall AHI (p=0.05, R=-0.50), NREM AHI (p= 0.04, r=-0.51) and REM AHI (p=0.05,r=-0.52)Conclusion: Our results suggest that there is a statistical significant trend between reduced lung volumes and AHI during the vulnerable period of REM sleep. The lack of strong statistical correlations between PFT's and SDB parameters might related to the fact that PFT's routinelly are performed with the patient in the upright and not the supine position. ER -