TY - JOUR T1 - Peripheral muscle strength and exercise capacity in children with cystic fibrosis and non-cystic fibrosis JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P4769 AU - Baki Umut Tugay AU - Hulya Arikan AU - Ugur Özçelik AU - Nazan Tugay Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P4769.abstract N2 - Cystic fibrosis (CF) is a chronic disease associated with pulmonary involvement, malnutrition, increased respiratory muscle work and musculoskeletal manifestations. Bronchiectasis not caused by CF is often perceived to be rare in western societies, but remains an important cause of chronic suppurative lung disease in the developing world among children. Therefore the aim of this study is to document the differences in exercise response and the possible underlying mechanisms between CF and non-CF patient groups. 24 patients with non-CF bronchiectasis (mean age 13.2(3.4) years) and 24 patients with CF (mean age 11.6(3.3) years) participated in the study. Pulmonary function testing and 6 minute walk test (MWT) were performed and peripheral muscle strength was measured by a hand held digital manual muscle tester to selected muscles. There was no significant difference between the physical characteristics, pulmonary functions, peripheral muscle strength and the distance walked in the 6 MWT (p>0.05). Non-CF patient group reached higher heart rate and maximum heart rate percentage in the 6 MWT (p<0.05). Distance walked in 6 MWT was significantly correlated with lean body mass (r: 0.613, p<0.001), maximum voluntary ventilation (r: 0.497, p<0.01) and peripheral muscle strength (r: 0.510, p<0.01) in the CF group. There was no relation between the exercise responses and pulmonary and nutritional factors in non-CF patients (p>0.05). Our data suggests that the major limitation to exercise seems to be related to nutritional factors in CF patients. ER -