PT - JOURNAL ARTICLE AU - Valentina Pinelli AU - Elisa Roca AU - Sophie Laroumagne AU - Silvia Lucchini AU - Gian Franco Tassi AU - Philippe Astoul TI - Relevance of FDG-PET-CT scan for the evaluation of local pleural invasion assessed by thoracoscopy in malignant pleural mesothelioma DP - 2012 Sep 01 TA - European Respiratory Journal PG - P4622 VI - 40 IP - Suppl 56 4099 - http://erj.ersjournals.com/content/40/Suppl_56/P4622.short 4100 - http://erj.ersjournals.com/content/40/Suppl_56/P4622.full SO - Eur Respir J2012 Sep 01; 40 AB - INTRODUCTION: FDG-PET-CT scan(PET) is now widely recognized as an important staging modality in many cancers and PET standard uptake value(SUV) is reported as a prognostic indicator in several malignancies. However only a few previous studies have investigated the utility of PET in malignant pleural mesothelioma(MPM). We hypothesized that pleural assessed by PET might be in accordance to pleural characteristics evaluated by thoracoscopy.METHODS: 29 patients with a diagnosis of MPM obtained by thoracoscopy were previously evaluated byPET, and considered valuable for this analysis. Among them, 10.34%, 20.69%, 44.83%, 24.14% were assessed as I,II, III, IV stage respectively. There were 10.34% of patients in stage I, 20.69% in stage II, 44.83% in stage III, and 24.14% in stage IV. The histological analysis showed 86.21% epithelioid, 3.45% sarcomatous and 10.34% biphasic types.RESULTS: At thoracoscopy there were 16 (55.17%) patients with visceral pleural involvement, 21 (72.41%) with diaphragmatic involvement and 2 (6.90%) with mediastinal involvement. All of them had an invasion of the costal parietal pleura. There was a significant difference (<0.05) of the medium SUV between the patients with a visceral pleural involvement and the patients without this feature. Moreover statistically significant differences of the medium SUV was shown between patients with or without pleural nodules.CONCLUSIONS: These findings suggest that pleural evaluation by PET should in accordance to the characteristics obtained by thoracoscopy. There is a significant difference between the site of pleural involvement and/or the typology of tumoral lesions and the SUV of PET.