RT Journal Article
SR Electronic
T1 Upper and lower airway nitric oxide levels in primary ciliary dyskinesia
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P4611
VO 40
IS Suppl 56
A1 Annabelle Liew
A1 Walker Woolf
A1 Amanda Harris
A1 Janice Coles
A1 Jane Lucas
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P4611.abstract
AB IntroductionPatients with primary ciliary dyskinesia (PCD) have low nasal nitric oxide (nNO) and fractional exhaled NO (FeNO). The reasons are unclear but might be related to ciliary function. Analysis of nitric oxide (NO) from different regions of the airway and comparisons with other disease states may guide our understanding.AimTo compare differential bronchial (JNO) and alveolar (CalvNO) NO in patients with PCD, cystic fibrosis (CF), asthma and healthy subjects.MethodsExhaled NO at different flow rates (50, 100, 200 and 250 ml/s) and nNO were measured (NIOX flex®, Aerocrine, Sweden) in patients with PCD (n=12), asthma (n=18), CF (n=12) and healthy controls (n=17). JNO and CalvNO were derived using a model of pulmonary NO exchange-dynamics.ResultsFeNO50 and nNO were significantly lower in PCD than in healthy subjects, as was JNO, 271 pl/s (228) vs. 965 pl/s (963) (p=0.004) (mean (SD)). However CalvNO was similar between the two, 1.6 ppb (0.5) vs. 2.4 ppb (1.4) (p=0.174). (Table 1 for CF and asthma data)View this table:Table 1 - Nitric oxide readings by respiratory diseaseConclusionPCD patients have significantly lower JNO but similar CalvNO to healthy controls. As there are no cilia in the alveolar region this might support the hypothesis that NO biosynthesis is coupled to ciliary function. Data collection continues.