%0 Journal Article %A James Moss %A Garry A. Tew %A Robert J. Copeland %A John M. Saxton %A Edward M. Winter %A Stephen M. Bianchi %T Effects of a lifestyle intervention in obese obstructive sleep apnoea patients treated with CPAP %D 2012 %J European Respiratory Journal %P P3862 %V 40 %N Suppl 56 %X Obstructive sleep apnoea (OSA) is a common condition characterised by repetitive closures of the upper airway during sleep. CPAP is the primary treatment and lifestyle changes are recommended, but there is no agreed structured intervention.This RCT assessed responses to a lifestyle intervention that incorporated exercise, dietary advice and behaviour change counselling. We hypothesised that the intervention would have a positive effect on anthropometry, functional capacity, cardiovascular risk and quality of life.Sixty OSA patients were recruited either into an intervention (n=30) or control group (n=30). Assessments occurred at week 0, week 13 and week 26. The intervention involved supervised exercise sessions, dietary advice and behaviour change counselling between weeks 0 and 13. Changes in body habitus and walking capacity (ISWD) between week 0, 13 and 26 were assessed using a mixed-design factorial ANOVA and 95% confidence intervals (CIs) of the net change in groups over time.At 13 weeks, the intervention group improved body mass (-1.7kg; P=0.001) and body fat percentage (-1.1 %; P =0.001) relative to the control group, although CIs between groups over time indicate changes were not clinically important. Changes in resting heart rate (-6 [-9, -2] beatsâ‹…min-1; P=0.002) and ISWD (+91 [52, 130] m; P<0.001) were possibly beneficial. At follow-up, changes in resting heart rate were likely trivial (-3 [-8, 1]; beatsâ‹…min-1; P=0.250) although ISWD was probably beneficial (+110 [71, 149] m; P<0.001).These data suggest that a change towards exercise behaviour has occurred. Interventions have potential as part of the holistic management of obese OSA patients compliant with CPAP. %U https://erj.ersjournals.com/content/erj/40/Suppl_56/P3862.full.pdf