RT Journal Article SR Electronic T1 Asthma remission and longitudinal changes in control in the Italian Study on Asthma in the Young Adults (ISAYA) JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P3954 VO 40 IS Suppl 56 A1 Amelia Grosso A1 Lucia Cazzoletti A1 Angelo Corsico A1 Federica Albicini A1 Erica Gini A1 Vanessa Ronzoni A1 Eti Maria Giulia Di Vincenzo A1 Roberto de Marco A1 Isa Cerveri YR 2012 UL http://erj.ersjournals.com/content/40/Suppl_56/P3954.abstract AB There is a little information on asthma remission and longitudinal changes in control in the last decade. In the frame of the ISAYA, a random sample of 354 asthmatics identified between 1998 and 2000 in 6 Italian centres (Pavia, Torino, Verona, Pisa, Sassari, Sassuolo) was followed-up 10 years apart (response rate 60%). At follow-up, asthma was considered in remission if a subject did not report any asthma-like symptom or drug use in the last year. A modified version of the GINA classification of asthma control, based on the frequency of diurnal and nocturnal symptoms, daily life activity limitations, and rescue medication use, was used. Out of the 210 subjects who participated in the follow-up, asthma had remitted in 61 (29%) subjects and was still present in 149 (71%). The likelihood of remission for subjects reporting asthma-like symptoms, attacks and asthma drug use at baseline was less than half the same risk in subjects who did not report them, as evaluated by means of a logistic model. Among non remittent subjects, 41 (28%) had controlled, 60 (41%) partially controlled and 46 (31%) uncontrolled asthma at baseline. Among 138 subjects with information at follow-up, 38 (28%) had controlled, 69 (50%) partially controlled and 31 (22%) uncontrolled asthma. At a multinomial logistic model, women were more likely to have partially or uncontrolled asthma than men; increasing age, chronic cough and phlegm and total or partial lack of control at baseline increased the risk of uncontrolled asthma at follow-up. More than 1 out of 4 subjects with asthma recover from their illness; however, less than 30% of the remaining subjects had controlled asthma a decade after.