@article {RavaP4754, author = {Marta Rava and Nicole Le Moual and Xavier Dumont and Stefano Guerra and Valerie Siroux and Benedicte Jacquemin and Alfred Bernard and Francine Kauffmann and Rachel Nadif}, title = {Association between serum clara cell secretory protein (CC-16) levels and asthma-related phenotypes among adults from the EGEA study}, volume = {40}, number = {Suppl 56}, elocation-id = {P4754}, year = {2012}, publisher = {European Respiratory Society}, abstract = {CC16 is a biological marker with anti-inflammatory and protective effects on the respiratory tract from oxidative stress. Lower levels of CC16 were observed in asthmatics, but this result has not been confirmed in any large epidemiological study. Associations between CC16, asthma and asthma-related phenotypes were studied in 1308 adults (43.7 yrs, 51.4\% women) from the French Epidemiological study on Genetics and Environment of Asthma (EGEA). Serum CC16 level was determined by ELISA. Estimates were adjusted for age, sex, smoking, pack-years, BMI and time of collection. Median (1st-3rd quartile) CC16 levels were 12.4 (8.02, 19.1) {\textmu}g/l (range: 2.1-70.6 {\textmu}g/l). CC16 levels decreased with female sex, BMI and pack-years and increased with age. No association was observed between CC16 level and current asthma. In asthmatics, CC16 levels decreased with severe persistent asthma compared to intermittent asthma.View this table:CC16 level may be related with asthma severity. Further studies are needed to clarify this association.Funded by NETA project, ERS fellowship 123-2011.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/40/Suppl_56/P4754}, eprint = {https://erj.ersjournals.com/content/40/Suppl_56/P4754.full.pdf}, journal = {European Respiratory Journal} }