PT  - JOURNAL ARTICLE
AU  - Milada Hobzova
AU  - Eliska Sovova
AU  - David Stejskal
AU  - Vitezslav Kolek
AU  - Jana Zapletalova
AU  - Milan Sova
TI  - Positive effect of CPAP therapy in OSA patients on A-FABP, CRP and triacylglycerols levels and diastolic blood pressure
DP  - 2012 Sep 01
TA  - European Respiratory Journal
PG  - P3804
VI  - 40
IP  - Suppl 56
4099  - http://erj.ersjournals.com/content/40/Suppl_56/P3804.short
4100  - http://erj.ersjournals.com/content/40/Suppl_56/P3804.full
SO  - Eur Respir J2012 Sep 01; 40
AB  - Objectives. Obstructive sleep apnea (OSA) can be associated with metabolic syndrome and cardiovascular disease (CVD). Adipocyte fatty acid-binding protein (A-FABP) may play a role in OSA. C-reactive protein (CRP) is a marker of inflammation and a risk factor for CVD. The study aimed to find whether continuous positive airway pressure (CPAP) treatment results in decreased serum A-FABP and CRP levels and their possible association. Subjects and methods. Eighty-one patients (70 males, a mean age of 53.9±10.3 years) diagnosed with OSA and indicated for CPAP treatment. Anthropometric, clinical and laboratory investigations were carried out and repeated after 1 year of CPAP treatment. Results. Patients had significantly decreased A-FABP levels (34.4 ng/mL; 24.8ng/mL; p=0.001), CRP levels (6.08±7.74; 4.29±4.9; p=0.007), triacylglycerols (2.24±0.88; 2.13±1.32; p=0.01), diastolic blood pressure (82±11; 79±7; p= 0.006) and improved OSA parameters: AHI (53.9; 5.6; p<0.0001), mean nocturnal oxygen saturation (91%; 94%, p<0.0001), ODI (55; 8, p<0.0001), t90 (28.2; 0; p<0.0001). BMI, waist, neck circumference, systolic blood pressure, total cholesterol, HDL cholesterol, LDL cholesterol, glucose and insulin did not change significantly. The decreases in A-FABP and CRP did not correlate significantly. Conclusion. CPAP therapy of OSA patients has a positive effect on A-FABP and CRP levels. Given the fact that changes in A-FABP and CRP do not correlate with each other, they may reflect the effect of various pathological events in the development of CVD. Decreased A-FABP and CRP levels may contribute to fewer cardiovascular complications of OSA after CPAP therapy.