RT Journal Article SR Electronic T1 Wheezing and pneumonia during the first year of life: An international epidemiological approach JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P4659 VO 40 IS Suppl 56 A1 Luis García-Marcos A1 Javier Mallol A1 Manuel Sánchez-Solís A1 Dirceu Solé A1 Paul L.P. Brand A1 EISL Study Group YR 2012 UL http://erj.ersjournals.com/content/40/Suppl_56/P4659.abstract AB Aims: To investigate risk factors of bronchopneumonia (BP) in wheezing (WZ) or non-WZ infants (at least 1 episode) in the “Estudio Internacional de Sibilancias en Lactantes" (EISL).Methods: EISL methods were described previously (Thorax 2010;65:1004-9). Briefly, parents from 22 centres (14 Latin American and 8 European) answered a validated questionnaire (Int Arch Allergy Immunol 2007;144:44-50) on wheezing and risk factors during the 1st year of life of their children. They were grouped as BP+WZ+; BP+WZ-; BP-WZ+; and BP-WZ- (comparator). Associations (aOR 95%CI) were tested using multivariate random-effects logit models, with centre as the panel variable.Results: Infants grouped: BP+WZ+ 3415; BP+WZ- 913; BP-WZ+ 11688; BP-WZ-18659. Among WZ+, BP was less likely to occur when correctly vaccinated (aOR: 0.68; 0.54-0.85 vs 0.90; 0.77-1.04). Among BP+, risk factors were different depending on WZ (table)View this table:Conclusions: In infants who had BN during the 1st year of life, there are some risk factors which are different for WZ+ and WZ-.