RT Journal Article SR Electronic T1 Short-term effects of quitting smoking in TNF-α and interleukin-10 serum and nasal lavage levels JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P4088 VO 40 IS Suppl 56 A1 Marceli Rocha Leite A1 Dionei Ramos A1 Rafaella Fagundes Xavier A1 Juliana Tiyaki Ito A1 Fernanda Maria Machado Rodrigues A1 Juliana Nicolino A1 Alessandra Choqueta de Toledo A1 Ercy Mara Cipulo Ramos YR 2012 UL http://erj.ersjournals.com/content/40/Suppl_56/P4088.abstract AB Some systemic benefits of quitting smoking are known, however, the immediate effects on inflammatory biomarkers have not been well described. The purpose of this study was to evaluate inflammatory biomarkers during a smoking cessation program (SCP). Twenty two abstinent smokers (age 50 [40-55] years; 13 [6-38] pack/years index; FEV1% 92,5 [87-104] enrolled in a SCP were evaluated at baseline and after 7, 15, 30 and 60 days of abstinence. The measurements of TNFα and interleukin-10 (IL-10) levels on nasal lavage and blood plasma (ELISA) and exhaled carbon monoxide (eCO), carboxyhaemoglobin (COHb). Current smokers (n=9; age 54[50-60] years; 28[19-42] pack/years index; FEV1% 96 [82-104] and non-smokers (n=8; age 53 [33-60] years; FEV1% 104,5 [93,5-106]) were also evaluated at the same time points. Statistical analyses were performed using One-way ANOVA followed by Tukey for parametric data and Kruskal-Wallis test followed by Dunn's test for non parametric data. There was a significant decrease in eCO and COHb in abstinent smokers after 7, 15, 30 and 60 days of abstinence (p<0,0001). There was a significant decrease in TNF-α levels on nasal lavage in abstinent smokers after 60 days of abstinence (p=0,0186). For TNF-α levels on blond plasma and IL-10 on blond plasma and nasal lavage there was no observed significant difference. The abstinence promoted decreased exCO and COHb levels after 7 days, decreased in TNF-α levels on nasal lavage in 60 days and of abstinence.