TY - JOUR T1 - Short-term effects of quitting smoking in TNF-α and interleukin-10 serum and nasal lavage levels JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P4088 AU - Marceli Rocha Leite AU - Dionei Ramos AU - Rafaella Fagundes Xavier AU - Juliana Tiyaki Ito AU - Fernanda Maria Machado Rodrigues AU - Juliana Nicolino AU - Alessandra Choqueta de Toledo AU - Ercy Mara Cipulo Ramos Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P4088.abstract N2 - Some systemic benefits of quitting smoking are known, however, the immediate effects on inflammatory biomarkers have not been well described. The purpose of this study was to evaluate inflammatory biomarkers during a smoking cessation program (SCP). Twenty two abstinent smokers (age 50 [40-55] years; 13 [6-38] pack/years index; FEV1% 92,5 [87-104] enrolled in a SCP were evaluated at baseline and after 7, 15, 30 and 60 days of abstinence. The measurements of TNFα and interleukin-10 (IL-10) levels on nasal lavage and blood plasma (ELISA) and exhaled carbon monoxide (eCO), carboxyhaemoglobin (COHb). Current smokers (n=9; age 54[50-60] years; 28[19-42] pack/years index; FEV1% 96 [82-104] and non-smokers (n=8; age 53 [33-60] years; FEV1% 104,5 [93,5-106]) were also evaluated at the same time points. Statistical analyses were performed using One-way ANOVA followed by Tukey for parametric data and Kruskal-Wallis test followed by Dunn's test for non parametric data. There was a significant decrease in eCO and COHb in abstinent smokers after 7, 15, 30 and 60 days of abstinence (p<0,0001). There was a significant decrease in TNF-α levels on nasal lavage in abstinent smokers after 60 days of abstinence (p=0,0186). For TNF-α levels on blond plasma and IL-10 on blond plasma and nasal lavage there was no observed significant difference. The abstinence promoted decreased exCO and COHb levels after 7 days, decreased in TNF-α levels on nasal lavage in 60 days and of abstinence. ER -