RT Journal Article SR Electronic T1 Tidal N2 washout ventilation inhomogeneity indices in a reference population aged 7-70 years JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P3797 VO 40 IS Suppl 56 A1 Birgitta Houltz A1 Kent Green A1 Anders Lindblad A1 Florian Singer A1 Paul Robinson A1 Kim Nielsen A1 Per Gustafsson YR 2012 UL http://erj.ersjournals.com/content/40/Suppl_56/P3797.abstract AB Background: The Multiple Breath inert gas Washout (MBW) method is increasingly used in research studies to assess ventilation distribution inhomogeneity. Normative data are needed when using the method clinically.Methods: Spirometry and triplets of nitrogen (N2) MBW using a new device (Exhalyzer D, EcoMedics AG, Duernten, Switzerland) were recorded in 284 healthy subjects aged 7-70 yrs. Mean and SD were calculated in four age groups for LCI (Lung Clearance Index), indices of peripheral airway function based on concentration normalized slope III analysis (Scond, Sacin, Pacin), concentration normalized end-tidal N2 after 6 lung volume turnovers (Cn TO6), washout time (WoT) and moment ratios (m1/m0; m2/m0).Results are tabulated.View this table:Demography and Results (mean (SD))Conclusion: Reference values for several different indices of ventilation distribution inhomogeneity obtained in a large healthy population over a wide age range are now available allowing for clinical use of this new N2 MBW method.