TY - JOUR T1 - Exercise training is beneficial in patients with non-cystic fibrosis bronchiectasis - A multi-centre, randomised controlled trial JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - 2834 AU - Annemarie Lee AU - Catherine Hill AU - Nola Cecins AU - Sue Jenkins AU - Christine McDonald AU - Angela Burge AU - Linda Rautela AU - Robert Stirling AU - Philip Thompson AU - Anne Holland Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/2834.abstract N2 - Background: Non-cystic fibrosis (CF) bronchiectasis is characterised by chronic cough and sputum production, exercise limitation and reduced quality of life (QOL), but the role of exercise training in this patient group is unclear. The aim of this study was to determine the effects of exercise training on cough-related symptoms, QOL and exercise capacity.Methods: Participants with non-CF bronchiectasis with a modified Medical Research Council dyspnoea score ≥1 were randomised to receive eight weeks of twice-weekly supervised exercise training or twice-weekly telephone support. The incremental shuttle walk distance (ISWD), 6-minute walk distance (6MWD), the Chronic Respiratory Disease Questionnaire, Leicester Cough Questionnaire and Hospital Anxiety and Depression Scale were measured by a blinded assessor at baseline and following intervention.Results: Eighty-five participants, aged (mean [SD]) 64 (13) years, FEV1 74 (22)% predicted and median modified Medical Research Council score of 1(IQR 3) were included. Of those in the exercise training group (n=42), 35 (83%) completed the program. There was a greater magnitude of change in the ISWD (mean difference 62m, 95% CI 24 to 101m) and the 6MWD (mean difference 41m, 95% CI 19 to 63m) in the exercise training group compared to the control group. Exercise training significantly reduced dyspnoea (p = 0.009) and fatigue (p = 0.01) but there was no difference in cough-related QOL or mood between groups.Conclusions: Exercise training in non-CF bronchiectasis improves exercise capacity and symptoms of dyspnoea and fatigue. Ongoing follow up will assess changes in these effects over time. ER -