TY - JOUR T1 - The value of magnesium sulfate nebulization in treatment of acute bronchial asthma during pregnancy JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P1789 AU - Mohamed Badawy AU - Ibrahim Hasannen Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P1789.abstract N2 - Little is known about the effect of inhaled Mg sulfate when added to B2 agonist in acute asthma with pregnancy. Objective: To evaluate the bronchodilator effect of nebulized magnesium sulfate with B2 agonist in the treatment of acute asthma during pregnancy, and its safety on pregnancy outcome. Material and methods: Patients were divided into two groups in a double blind randomization. Group A" received the routine treatment of acute asthma exacerbation plus nebulized salbutamol in dose of (1 ml of salbutamol solution dissolved in 9 ml of normal saline). "Group B" received the same above treatment plus (500 mg (1ml) of magnesium sulfate). Two hours after three sets of nebulization pulmonary function test and blood gas analysis were done. Results: Sixty pregnant women's with acute asthma, 30 patients in each group with mean age were (25.9± 4.01 & 25.7±3.8) in both groups respectively. Comparison between both groups in pulse rate, arterial oxygen tension and oxygen saturation were highly significant (P<0.001). FEV1 was (32.68±7.15&56.31±8.25) in group A& B respectively and the percentage of change was 69 % with (highly significant P value <0.001). The frequency of acute asthma exacerbation till delivery in both groups was (3.2± 0.98 & 0.4 ± 0.57) in group A and B respectively (95% CI 2.4 to 3.1) with highly significant p value (P<0.001). All patients were delivered either normal delivery (60% & 66.6%) or C.S (40%& 33.6%) with smooth neonatal period. Conclusion: Adding magnesium sulfate to salbutamol nebulization as a therapy for acute asthma during pregnancy is effective and safe. The availability, cheapness of this drug especially for the developing countries added to its advantage. ER -