RT Journal Article
SR Electronic
T1 Clinical analysis of adverse reactions to second line anti TB drugs
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2579
VO 40
IS Suppl 56
A1 Alpa Dalal
A1 Ranjan Desai
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P2579.abstract
AB Introduction: Adverse reactions to second line anti T B drugs not only leads to permanent system damage in patients but also MDR/XDR treatment failureAims and Objective: MDR/XDR TB patients on second line anti T B drugs were analysed clinicaly for adverse reactions.These patients underwent pretreatment counselling for possible adverse reactions to improve treatment adherance.Methods: 146 patients with MDR/XDR T B on second line drugs were analysed. These adverse reactions were classified in to two groups. Severity based and system based. Severity further classified as 1) mild not requiring discontinuation of drugs 2) those requiring temporary discontinuation 3) requiring permanent discontinuation.Results: 47.9 % had no adverse reactions. 21.3% had mild reactions.11.6% required temporary discontinuation and 19.2% required permanent discontinuation.Gastrointestinal were commenest system based reaction effecting 30% of patients Followed by Peripheral neuritis 18.4%, Endocrinal (hypothyroidism)10.5%, Auditary and vestibular(deafness)9.2%, Ophthalmic (optic neuritis)6.5%,Hepatic 5.2%,Joint pains 5.2%,Psychiatric disturbance 1.3% and 19.7%patients had more than one system involved.Majority of patients with peripheral neuritis,optic neuritis and hypothyroidism required discontinuation of offending drug.Conclusion: Significant number of patients developed adverse reaction including very severe reaction requiring discontinuation of drug which may effect treatment outcome.close monitoring and patient counselling is necessary to prevent permanent system damage and discontinuation of therapy.