RT Journal Article
SR Electronic
T1 Ciliary function of the nasal and bronchial epithelium in children with cystic fibrosis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P1448
VO 40
IS Suppl 56
A1 Biju Thomas
A1 Paul Aurora
A1 Helen Spencer
A1 Andrew Rutman
A1 Rob A. Hirst
A1 Chris O'Callaghan
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P1448.abstract
AB BackgroundNormal ciliary function is essential in pulmonary defence. It is unclear if there is any difference in ciliary function between the nasal and the bronchial epithelium, in children with Cystic Fibrosis (CF).AimsOur aim was to determine if there is any difference in ciliary function between the nasal and the bronchial epithelium, in children with CF.Methods9 children with CF (2 males, median [IQR] age: 14.1 [12.8-15.7] years, median [IQR] duration post transplant: 12 [2.9-15.5] months), who had lung transplantation at the GOS Hospital for Children (London, UK) were studied. Nasal brushings and bronchoscopic bronchial brushings from the lower airway above the anastomosis were studied using digital high speed video camera to determine the ciliary beat frequency (CBF) and beat pattern, as described previously. (Thomas B. et al. Eur Respir J. 2009;34:401-4).ResultsThere was no significant difference in CBF or beat pattern between the epithelium of the nose and the lower airway, in children with CF (Table 1). However, the CF nasal epithelium showed significantly lower CBF and higher dyskinesia index compared to that of healthy children (Data published previously, Table 1)View this table:Table 1ConclusionThere was no difference in ciliary function between the nasal and the bronchial epithelium in paediatric CF lung transplant recipients.