RT Journal Article
SR Electronic
T1 Respiratory functional status after intrapleural t-PA administration for complicated parapneumonic effusions
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2538
VO 40
IS Suppl 56
A1 Dionisios Spyratos
A1 Maria Sionidou
A1 Marina Antoniou
A1 Theodoros Kontakiotis
A1 Konstantinos Zarogolidis
A1 Lazaros Sichletidis
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P2538.abstract
AB Background: In a multicentered randomized trial, intrapleural administration of streptokinase has been proved unsuccessful.Aims: To investigate lung function and exercise capacity after intrapleural administration of t-PA in patients with complicated parapneumonic pleural effusion (CPE).Methods: 18 consecutive patients with CPE were included. Chest tube was inserted under guidance of CT. After pleural fluid drainage has stopped, 25 mg t-PA/day was administered for 2 consecutive days. We evaluated patients with spirometry before t-PA, one day after chest tube removal and one month after discharge. During the second and third time-points, 6 minute walking test was also performed.Results: Patients reported symptoms 10.2±6.8 days days before hospital admission while all have demonstrated loculated effusions. The mean production of fluid was 717±775 ml before and 1.516±240 ml after t-PA administration (p<0.001). Lung function and exercise capacity tests are presented on table 1. Adverse events were pain (9/18) and minor bleeding (2/18) at the site of insertion.Conclusion: Intrapleural administration of t-PA for CPE was an effective treatment considering lng function status during follow-up.View this table: