RT Journal Article SR Electronic T1 Clinical impact of the relationship between low bone mineral density and peripheral muscle strength in patients with COPD JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P1152 VO 40 IS Suppl 56 A1 Glenn Leemans A1 Kris M.H. Ides A1 Lieve De Backer A1 Hilde Vaerenberg A1 Kevin De Soomer A1 Dirk Vissers A1 Wilfried De Backer YR 2012 UL http://erj.ersjournals.com/content/40/Suppl_56/P1152.abstract AB IntroductionCOPD is a respiratory disease with systemic consequences such as osteoporosis. It is known that this impaired bone mineral density (BMD) correlates with physical inactivity. If physical inactivity does depend on muscle strength, a correlation between muscle strength and osteoporosis must exist.ObjectiveTo evaluate how strong peripheral muscle strength is related to the loss of BMD in our COPD population.MethodsData of 11 patients in a pulmonary rehabilitation program is analysed. BMD at the lumbar spine and hip is determined by dual-energy X-ray absorption (DXA). DXA is performed based upon the patient's risk profile (long history of corticosteriods). The BMD is expressed as a T score. Isometric quadriceps force (IQF) is assessed by a computerized dynamometer during a voluntary maximal isometric contraction with the hip at 90° and the knee at 60° flexion. The highest value is taken.ResultsA significant correlation is found between T score lumbar spine and IQF in % predicted of the normal value (R=0.627; p=0.039). IQF is not related to the T score of the hip (p=0.385).ConclusionsLower BMD in the lumbar spine seems to relate with lower IQF in our COPD population. Strengthening of those quadriceps muscles in this specific COPD patients must therefore best be done in an upright, weight-bearing position during closed chain exercises to stabilise or increase the BMD of the lumbar spine.