TY - JOUR T1 - Predicting mortality in patients hospitalised with acute exacerbations of COPD (AECOPD) requiring assisted ventilation JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - 4558 AU - John Steer AU - John Gibson AU - Stephen Bourke Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/4558.abstract N2 - BackgroundPrognostic studies in AECOPD requiring assisted ventilation often select patients by place of care and predict failure of non-invasive ventilation (NIV), not mortality. Improved mortality prediction for unselected patients requiring ventilation for AECOPD is needed.ObjectiveIdentify mortality predictors in patients with AECOPD requiring ventilatory assistance.MethodsClinical data were collected on consecutive patients hospitalised with AECOPD requiring assisted ventilation (NIV or invasive ventilation) for acidaemic respiratory failure (ARF) during their hospital stay. Independent predictors of in-hospital mortality were identified.Results199 received ventilatory assistance: mean (SD) age = 73.9 (9.8) years; FEV1 38.1 (16.1) % predicted and 61.3% were female. 49 (24.6%) patients died in hospital.Older age, an ineffective cough, and severe stable-state dyspnoea were the strongest mortality predictors. The regression model (table 1) showed excellent discrimination for mortality (AUROC = 0.92, 0.88 to 0.96).View this table:Table 1. Independent predictors of mortalityConclusionMortality in patients hospitalised with AECOPD requiring assisted ventilation is high but can be accurately predicted using simple to measure indices. ER -