PT  - JOURNAL ARTICLE
AU  - Adam Domonkos Tarnoki
AU  - David Laszlo Tarnoki
AU  - Zsofia Lazar
AU  - Kinga Karlinger
AU  - Andrea Agnes Molnar
AU  - Zsolt Garami
AU  - Viktor Berczi
AU  - Ildiko Horvath
TI  - Role of genetic factors on smoking habits and secondhand smoke sensitivity: A twin study
DP  - 2012 Sep 01
TA  - European Respiratory Journal
PG  - 4511
VI  - 40
IP  - Suppl 56
4099  - http://erj.ersjournals.com/content/40/Suppl_56/4511.short
4100  - http://erj.ersjournals.com/content/40/Suppl_56/4511.full
SO  - Eur Respir J2012 Sep 01; 40
AB  - Introduction: The role of genetic factors on nicotine dependence, withdrawal and quitting is well understood, however no information is available on secondhand smoke (SHS) exposure sensibility. Our aim was to assess SHS exposure, smoking habits and characteristics, smoking regulations at home, during driving and at workplace of monozygotic (MZ) and dizygotic (DZ) twins, and the contribution of genetic factors to SHS sensibility.Methods: 161 Hungarian and 50 American adult twin pairs (151 MZ and 62 DZ; mean age 44±17 years±standard deviation/SD/) were recruited in this classical twin study.Results: The overall rate of current, ex and never smokers was 14.6%, 16.4% and 69.2%. MZ twins reported higher rate of everyday and regular smoking for at least one year (p<0.05). 88% of MZ twins were both ex or current smokers, while the number was 70% in DZ twins (p<0.01). Significantly higher concordance was found in the disturbing effect of secondhand smoke in MZ versus DZ pairs (58 to 94% versus 39 to 79%, p<0.05 to p<0.005) on a self-reported smoke pollution scale between 1-7. Significantly smaller difference was observed in self-reported smoke pollution rate in MZ twins compared to DZ pairs concerning the restaurants and cafés (1.2±1.3 vs 1.8±1.5, p<0.05) which was not present regarding restaurants and cafés and transportation facilities.Conclusions: In conclusion, this study estimated a genetic influence on smoking habits and secondhand smoke sensibility especially in smoke pollution rate of restaurants and cafés.