%0 Journal Article %A Liudmyla Iashyna %A Yuriy Feshchenko %A Svitlana Moskalenko %A Inna Zvol %A Irina Chumak %T Complex approach in the study of clinical and functional features in patients with severe bronchial asthma with and without respiratory disorder during sleep %D 2012 %J European Respiratory Journal %P P889 %V 40 %N Suppl 56 %X Aim of study: comparison of clinical and functional diagnostic criteria in patients with severe bronchial asthma and in combination with obstructive sleep apnea.Materials and methods: 60 patients with severe asthma were divided into 2 groups: I group of patients with OSA were 30 patients (16 women and 14 men age (58,8 ± 2,2) years) and II group of patients without OSA consisted of 17 women and 13 men age (50,5 ± 2,1) years. In both groups FEV1 ranged from (54,8 ± 3,1) to (58,2 ± 2,6)%).The following studies were performed: respiratory function, polysomnography, daily blood pressure measurement, Holter monitoring of ECG.Results: Asthma Control Test score revealed that patients with OSA had poor control of asthma symptoms (15,0 ± 4,7) compared to patients without OSA (18,0 ± 4,7) and higher scores for breathlessness scale MRCDS. Results of the questionnaire SQRG found that patients with OSA had more symptoms due to asthma and significant limitation of activity (67,1 ± 3,8) than patients without OSA (60,2 ± 4,7) (p <0.05). Patients with OSA had an increase in pulse blood preassure, minimum of daily, a maximum of night, and a marked increase in the average heart rate per night, the increase variability in blood pressure. in the night period, compared with patients without OSA, p <0.05.Conclusion: the use of a wide range of diagnostic methods will allow for an adequate pathogenetic treatment and improvement of disease control in patients with severe asthma and in combination OSA. %U https://erj.ersjournals.com/content/erj/40/Suppl_56/P889.full.pdf