RT Journal Article SR Electronic T1 Acute effect of inhaled corticosteroid on exhaled breath temperature in asthmatic patients JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 4306 VO 40 IS Suppl 56 A1 Tanya Kralimarkova A1 Vasil Dimitrov A1 Todor Popov YR 2012 UL http://erj.ersjournals.com/content/40/Suppl_56/4306.abstract AB Background: Measurement of exhaled breath temperature (EBT) with a portable hand held device is applicable as a non-invasive method to monitor the control of asthma. While inhaled corticosteroids (ICS) have proven suppressive effect on airway inflammation decreasing EBT in the long run, there is no data on the immediate effect of inhaling them. The aim of this study was to explore the acute effect of ICS on EBT.Methods: We recruited 21 subjects (mean age 47 years, 12 women) from among the patients of the Clinic of Allergy and Asthma in Sofia, Bulgaria: 12 were with controlled; 9 with partly controlled asthma. Patients were randomized to inhale 2 puffs of either ciclesonide or placebo from identical looking inhalers in the morning of consecutive days. Spirometry and assessment of EBT by means of PHD (X-halo, Delmedica, Singapore) were performed before and at 4 time points (5, 30 60 and 120 min.) after inhalation.Results: Compared to baseline EBT (mean 33.78 ± s.e.m.0.10°C, ±), there was a significant increase in EBT 5 min. (34.17±0.10, P=0.001), 30 min. (34.07±0.10, P=0.002), and 60 minutes (33.90±0.10, P=0.046) post ICS inhalation. The pre- / post- inhalation differences between ICS and placebo differed significantly (P=0.001). Inhalation of ICS and placebo did not bring about any significant changes in the spirometry of the patients. There was no difference between the controlled and the partly controlled asthmatics in EBT changes.Conclusions: EBT increases 1 hour after inhalation of ICS in a dose, prescribed for maintenance treatment of asthma. This needs to be taken into consideration if EBT is applied for monitoring of the disease.