RT Journal Article
SR Electronic
T1 Let us try pirfenidone in paraquat poisoning: Effect of pirfenidone on pulmonary fibrosis due to paraquat poisoning in rats
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P3765
VO 40
IS Suppl 56
A1 Soroush Seifirad
A1 Farzad Masoudkabir
A1 Shervin Taslimi
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P3765.abstract
AB Background: This study investigated the effectiveness of pirfenidone (PF) compared with antioxidants, in the prevention of pulmonary fibrosis and increasing the survival in acutely paraquat (PQ) poisoned rats.Methods: Fifty rats equally randomized into 5 groups. Three groups poisoned with intraperitoneal injection of 15 mg/kg PQ. From these three groups one also received vitamin C (500 mg/kg, IP), E (200mg/kg, IP) and N-acetylcysteine (250 mg/kg, IV). Two others received either Normal Saline (NS) or PF (200 mg/kg- IV). Two groups were not poisoned and received NS or PF (200mg/kg, IV). All injections except PQ repeated for another 4 times in consecutive days. On the 15th day of study or the corresponding day of death a semi-quantitative determination of lung fibrous was done using Ashcroft staging criteria on the lung sections.Results: PF decreased PQ induced lung fibrosis (P<0.001) while antioxidants did not decrease the lung fibrosis (p=0.413). Life expectancy decreased in PQ+NS (11 95% CI 7.94 to 14.05) and PQ+antioxidant (11 95%CI 7.77 to 14.23) groups. The increase in the survival of rats in PQ/PF group was insignificant (13.4 95% CI 11.13 to 15.67).Conclusion: This study showed that PF is able to decrease pulmonary fibrosis following PQ poisoning.