TY - JOUR T1 - Increased levels of soluble intercellular adhesion molecule 1 in active smokers JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P784 AU - Elena Arellano-Orden AU - Ana Montes-Worboys AU - Carmen Calero-Acuña AU - Eduardo Marquez-Martin AU - Pilar Cejudo-Ramos AU - Francisco Ortega-Ruiz AU - Jose Luis Lopez-Campos Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P784.abstract N2 - Objectives. Serum intercellular adhesion molecule-1 (sICAM-1) is known to be a smoking-associated inflammatory marker but data on the relationship between active smoking and sICAM-1 are lacking for COPD. In the present study we collected a group of COPD patients and non-COPD smokers and measured the sICAM-1 in order to provide information on its expression related to active smoking.Methods. This report is based on a cross sectional analysis of a case-control study, in which 141 COPD cases and 56 controls (non-COPD smokers) were consecutively recruited. Clinical information from all subjects was registered using a designed questionnaire that included direct questions on co-morbid conditions, respiratory symptoms and tobacco history. Peripheral blood concentration of sICAM-1, together with interleukin-8 (CXCL8), C-reactive protein (CRP), and serum amyloid A (SAA) were determined in all cases.Results. There were 89 ex-smokers and 108 active smokers of them in the sample. CRP and SAA (log-scale) were elevated in patients with COPD as compared to control subjects (p = 0.005 for CRP and p = 0.024 for AAS). SAA and sICAM-1 were associated with active smoking in the bivariate analysis. ICAM-1 retained this association when corrected by age, gender, the presence of COPD, inhaled corticosteroids use, body mass index, and FEV1 as covariates.Conclusion. The present study confirms an association between sICAM-1 levels and active smoking in a group of COPD and non-COPD smokers. This association is specific of ICAM, not affecting other COPD-related biomarkers. ER -