RT Journal Article SR Electronic T1 A randomised clinical trial to assess the effect of active muscle stimulation on hospitalised patients with COPD exacerbations JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P4775 VO 40 IS Suppl 56 A1 Timm Greulich A1 Maja Franke A1 Juliane Fechtel A1 Christoph Nell A1 Katharina Kehr A1 Silke Mueller A1 Harald Schubert A1 Klaus Kenn A1 Claus Vogelmeier A1 Andreas Rembert Koczulla YR 2012 UL http://erj.ersjournals.com/content/40/Suppl_56/P4775.abstract AB Introduction:Physical exercise reduces the detrimental effects of acute exacerbations in patients with chronic obstructive pulmonary disease (COPD). The Galileoâ„¢ system (Novotec Medical, Pforzheim, Germany) is based on the principle of active muscle contraction via extension reflex triggers.Aim:To assess the effect of active muscle stimulation in hospitalised COPD patients on exercise capacity, health-related quality of life (Qol), and inflammation.Methods:24 hospitalised COPD patients with an acute exacerbation were randomised to participate either in the standard physiotherapy programme (PT: physical and respiratory exercises) or in the standard programme with the addition of exercises on the Galileo device (PTG). On the days of admission and discharge we assessed: 6-minute walking test (6-MWT), COPD assessment test (CAT), and serum c-reactive protein (CRP).Results:The baseline characteristics are shown in table 1.View this table:While CRP decreased in both groups (p<0.05), we found a significant increase in the 6-MWT (p<0.005) and a significant decrease in the CAT (p<0.05) in the PTG group only (table 2).View this table:Conclusion:In patients hospitalised due to an exacerbation of COPD, the addition of active muscle contraction with the Galileo system results in beneficial effects on Qol and exercise capacity.