RT Journal Article SR Electronic T1 Drug resistance trends and patterns of mycobacterium tuberculosis isolates from pulmonary tuberculosis patients at a tertiary care hospital in Turkey JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P3331 VO 40 IS Suppl 56 A1 Esra Ertan Yazar A1 Birsen Pinar Yildiz A1 Gülsah Günlüoglu A1 Sedat Altin A1 Veysel Yilmaz A1 Derya Hirçin Cenger YR 2012 UL http://erj.ersjournals.com/content/40/Suppl_56/P3331.abstract AB OBJECTIVE:To determine the proportions and patterns of resistance to commonly used tuberculosis (TB) drugs (isoniazid [INH], rifampicin [R], ethambutol [E] and streptomycin[S]) among pulmonary TB patients and assess potential risk factors for drug resistance.METHODOLOGY:Strains were collected from 1584 sputum smear negative or positive pulmonary TB patients with culture positive in tertiary care hospital of Turkey. Specimens were cultured in liquid and solid media, and drug susceptibility tests were performed for first-line drugs including isoniazid, rifampin, streptomycin, ethambutol and pyrazinamide.RESULTS:Drug susceptibility testing (DST) has been obtained from all samples 442 (27.9 %) of 1584 isolates were resistant to at least one of five antibiotics tested. 300 (18.9 %) isolates were resistant to isoniazid; 168 (10.6 %) to streptomycin; 137 (8.6 %) to ethambutol; 220 (13.9 %) to rifampin. 146 isolates (9.2 %) were multidrug resistant, Results also showed 49 % of patients were below the age of 40 years.CONCLUSION:Regardless of previous treatment history, the high resistance observed in isoniazid, which is a first-line drug. Treating culture-positive TB patients based on DOTS together with strengthened control programs should therefore be considered in the management of TB patients.