PT  - JOURNAL ARTICLE
AU  - Esra Ertan Yazar
AU  - Birsen Pinar Yildiz
AU  - Gülsah Günlüoglu
AU  - Sedat Altin
AU  - Veysel Yilmaz
AU  - Derya Hirçin Cenger
TI  - Drug resistance trends and patterns of mycobacterium tuberculosis isolates from pulmonary tuberculosis patients at a tertiary care hospital in Turkey
DP  - 2012 Sep 01
TA  - European Respiratory Journal
PG  - P3331
VI  - 40
IP  - Suppl 56
4099  - http://erj.ersjournals.com/content/40/Suppl_56/P3331.short
4100  - http://erj.ersjournals.com/content/40/Suppl_56/P3331.full
SO  - Eur Respir J2012 Sep 01; 40
AB  - OBJECTIVE:To determine the proportions and patterns of resistance to commonly used tuberculosis (TB) drugs (isoniazid [INH], rifampicin [R], ethambutol [E] and streptomycin[S]) among pulmonary TB patients and assess potential risk factors for drug resistance.METHODOLOGY:Strains were collected from 1584 sputum smear negative or positive pulmonary TB patients with culture positive in tertiary care hospital of Turkey. Specimens were cultured in liquid and solid media, and drug susceptibility tests were performed for first-line drugs including isoniazid, rifampin, streptomycin, ethambutol and pyrazinamide.RESULTS:Drug susceptibility testing (DST) has been obtained from all samples 442 (27.9 %) of 1584 isolates were resistant to at least one of five antibiotics tested. 300 (18.9 %) isolates were resistant to isoniazid; 168 (10.6 %) to streptomycin; 137 (8.6 %) to ethambutol; 220 (13.9 %) to rifampin. 146 isolates (9.2 %) were multidrug resistant, Results also showed 49 % of patients were below the age of 40 years.CONCLUSION:Regardless of previous treatment history, the high resistance observed in isoniazid, which is a first-line drug. Treating culture-positive TB patients based on DOTS together with strengthened control programs should therefore be considered in the management of TB patients.