TY - JOUR T1 - Drug resistance trends and patterns of mycobacterium tuberculosis isolates from pulmonary tuberculosis patients at a tertiary care hospital in Turkey JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P3331 AU - Esra Ertan Yazar AU - Birsen Pinar Yildiz AU - Gülsah Günlüoglu AU - Sedat Altin AU - Veysel Yilmaz AU - Derya Hirçin Cenger Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P3331.abstract N2 - OBJECTIVE:To determine the proportions and patterns of resistance to commonly used tuberculosis (TB) drugs (isoniazid [INH], rifampicin [R], ethambutol [E] and streptomycin[S]) among pulmonary TB patients and assess potential risk factors for drug resistance.METHODOLOGY:Strains were collected from 1584 sputum smear negative or positive pulmonary TB patients with culture positive in tertiary care hospital of Turkey. Specimens were cultured in liquid and solid media, and drug susceptibility tests were performed for first-line drugs including isoniazid, rifampin, streptomycin, ethambutol and pyrazinamide.RESULTS:Drug susceptibility testing (DST) has been obtained from all samples 442 (27.9 %) of 1584 isolates were resistant to at least one of five antibiotics tested. 300 (18.9 %) isolates were resistant to isoniazid; 168 (10.6 %) to streptomycin; 137 (8.6 %) to ethambutol; 220 (13.9 %) to rifampin. 146 isolates (9.2 %) were multidrug resistant, Results also showed 49 % of patients were below the age of 40 years.CONCLUSION:Regardless of previous treatment history, the high resistance observed in isoniazid, which is a first-line drug. Treating culture-positive TB patients based on DOTS together with strengthened control programs should therefore be considered in the management of TB patients. ER -