RT Journal Article
SR Electronic
T1 Association between obstructive sleep apnea and elevated levels of B-type natriuretic peptide in a community based sample of women
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P3194
VO 40
IS Suppl 56
A1 Mirjam Ljunggren
A1 Bertil Lindahl
A1 Jenny Theorell-Haglöw
A1 Eva Lindberg
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P3194.abstract
AB Background: Obstructive sleep apnea (OSA) is associated with an increased risk of cardiovascular disease and mortality. One contributory factor may be hemodynamic stress due to the negative intrathoracic pressure during each apnea. Type-B Natriuretic Peptide (BNP) is secreted by the cardiac ventricles in response to volume expansion and pressure load and we hypothesized that there would be an association between indices of obstructive sleep apnea in the night and levels of BNP in the morning.Methods: From a community-based sample, 349 women underwent full-night polysomnography, anthropometric measurements and answered a questionnaire about medical conditions and current medication. The morning following the polysomnography, blood samples were drawn for analysis of plasma BNP, C-reactive protein, creatinine and hemoglobin.Results: There was an increase in mean BNP as the severity of sleep apnea increased, increasing from a mean value of 8.5ng/L among women with an AHI of <5 to 18.0ng/L in women with an AHI of >30. Elevated BNP levels (>20ng/L) were found in 29.8% of the women, while 70.2% had normal levels. The odds ratio was 2.2 for elevated BNP levels for women with an AHI of 5-<15 in relation to women with an AHI of <5, 3.1 for women with an AHI of 15-<30 and 4.5 for women with an AHI of >30 after adjustment for age, BMI, systolic blood pressure, antihypertensive drugs and creatinine.Conclusions: We found a dose-response relationship between the severity of sleep apnea during the night in women and the levels of BNP in the morning.