%0 Journal Article %A Andrey Akopov %A Valentina Molodtcova %A Anatoly Rusanov %A Andrey Gerasin %A Nikita Kazakov %T Preoperative endobronchial photodynamic therapy improves surgical radicalism for locally advanced NSCLC %D 2012 %J European Respiratory Journal %P P662 %V 40 %N Suppl 56 %X Objective. We describe the result of prospective randomized trial comparing neoadjuvant chemotherapy with and without endobronchial photodynamic therapy (PDT) followed by surgery for locally advanced NSCLC.Methods. From Jan 2008 to Dec 2011, 42 pts with stage III central NSCLC (main bronchus/distal trachea involvement) were randomized to either endobronchial PDT or no PDT. PDT was done with photosensitizer chlorine E6 and 662 nm laser light before each of the three courses of chemotherapy. Patients assigned to PDT (n=21) and no PDT (n=21) were similar with respect to age, sex, tumor stage, and histology.Results. No PDT complications were observed. After neoadjuvant treatment partial remission revealed in 19 pts (90%) in PDT and 16 pts (76%) in no PDT group, these patients underwent thoracotomy. Surgery in PDT group: 14 pneumonectomies and 5 lobectomies; surgery in no PDT group: 10 pneumonectomies, 3 lobectomies and 3 exploratory. There was one postoperative death in each group. Completeness of resection was significantly higher in PDT (R0-89%, R1-11%) vs. no PDT (R0-54%, R1-46%) group.Conclusions. Combination of chemotherapy with endobronchial PDT increases effectiveness of neoadjuvant treatment and surgical radicalism for locally advanced central NSCLC. %U https://erj.ersjournals.com/content/erj/40/Suppl_56/P662.full.pdf