@article {FedorovaP474, author = {Yuliya Fedorova and Alexandra Karunas and Galiya Gimalova and Nailya Ramazanova and Regina Murzina and Lilya Muchtarova and Elena Galimova and Radik Gatiyatullin and Shamil Zagidullin and Esfir Etkina and Elza Khusnutdinova}, title = {Association analysis of Β2-adrenergic receptor gene polymorphisms (Arg16Gly and Gln27Glu) with asthma in the Volga-Ural region of Russia}, volume = {40}, number = {Suppl 56}, elocation-id = {P474}, year = {2012}, publisher = {European Respiratory Society}, abstract = {The β2-adrenergic agonists are the most potent bronchodilators for the treatment of asthma. Genetic variation in the ADRB2 gene has been hypothesized to have a role in differential response to beta-agonist (BA) therapy in asthma. Two polymorphic variants rs1042713 (Gly16Arg) and rs1042714 (Gln27Glu) were genotyped in 618 patients with physician-diagnosed asthma, aged 2-60 years (192 Russians, 139 Tatars, 82 Bashkirs and 205 mixed origins), and 366 nonasthmatic individuals (123 Russians, 91 Tatars, 51 Bashkirs and 101 mixed origins) from the Volga-Ural region of Russia. Genotypes were determined by the PCR-RFLP method. Data were analyzed using the chi-square test with Haploview software. We found significant association of Gln27Glu polymorphism with mild decrease FEV1 (60-80\% of the predicted value) in Russian patients. The frequencies of genotype ADRB2*27Gln/27Gln and allele ADRB2*27Gln were increased in asthmatics of this group compared to controls (p=0,03, OR=2,25 (95\%CI 1,05-4,82) and p=0,02, OR=1,97 (95\%CI 1,11-3,50), accordingly). The analysis of Arg16Gly polymorphism showed significant association with moderate asthma in Tatars. The higher frequency of the ADRB2*16Gly/16Arg heterozygotes was revealed in the patients compared with controls (p=0,02, OR=2,25 (95\%CI 1,15-4,03)). In summary, these results suggest an important role for polymorphisms of gene ADRB2 in the development of asthma in the Volga-Ural region of Russia.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/40/Suppl_56/P474}, eprint = {https://erj.ersjournals.com/content/40/Suppl_56/P474.full.pdf}, journal = {European Respiratory Journal} }