TY - JOUR T1 - Tuberculosis in immunocompromised hosts: Pathogenetic and pathologic peculiarities JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P2624 AU - Maryna Dziusmikeyeva AU - Dzmitry Gorenok Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P2624.abstract N2 - Fast spreading of HIV-infection is one of the leading reasons of TB incidence increase. HIV-associated immunodeficiency leads to transition TB from infection to disease. Active TB strengthens HIV replication due to rapid synthesis of proinflammatory cytokines. In Belarus, the annual tendency to HIV-associated TB increase is observed. In 2002, a total of 35 HIV/TB patients was registered, whereas 265 in 2009.The purpose of study: to investigate pathogenetic and pathologic peculiarities of pulmonary TB in patients with HIV/AIDS.Methods: Morphological study of HIV/AIDS-associated TB was carried out on autopsy material of 11 patients died in center clinic in 2006-2010. The control group was 10 not HIV-infected TB patients.The causes of death in HIV-infected patients were generalized TB with extrapulmonary manifestations in 6 cases, caseous pneumonia in 2 cases, acute progressing disseminated TB in 3 patients. We distinguished following pathogenetic variants of associated HIV/TB pathology: HIV was primary, duration of observation before TB revealing 5-7 years; TB was primary, duration of observation before HIV revealing 1-3 years; HIV/TB were revealed simultaneously. Peculiarities of TB coursing in AIDS patients compared with non HIV-associated TB were: loss of wavy TB coursing signs and specific inflammation features; monomorphy of TB inflammation foci; prevalence of necrotic suppurative foci; absence of productive inflammation elements on foci periphery; absence of localization and organizations signs of TB foci.Morphological peculiarities of HIV/TB determine diagnostics complexity and require histobacteriological study with Ziehl-Nielsen staining. ER -