RT Journal Article
SR Electronic
T1 Effects of aerobic exercise training in cytokines levels on muscle of mice exposed to cigarette smoke
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P4065
VO 40
IS Suppl 56
A1 Alessandra Toledo
A1 Flavia Guarnier
A1 Camila Suehiro
A1 Renato Magalhães
A1 Rodolfo Vieira
A1 Mílton Martins
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P4065.abstract
AB Smoking has been shown to increase inflammatory biomarkers and exercise can influences this response. The purpose of our study was to evaluate the effects of physical training on cytokines levels on muscle of mice exposure to cigarette smoke. Methods: C57Bl6 mice were divided into 4 groups: Control, Smoke, Exercise and Smoke/Exercise. Smoke groups were exposed to cigarette smoke for 30min/day (twice), 5days/week for 4 weeks. Exercise groups were trained at moderate intensity for 60min/day, 5days/week for 4 weeks. TNFa, IL-6 and IL-10 levels were measured on muscle by ELISA. Results: IL6 and IL-10 increased after 4 weeks in Exercise and Smoke/Exercise groups (p<0.001, compared to smoke and control group). TNFa increased on Smoke group and exercise training inhibit this response (p<0.05). Conclusion: Our results suggest that AE training at moderate intensity have beneficial effects on inflammatory biomarkers in mice exposed to cigarette smoke.