RT Journal Article
SR Electronic
T1 Effect of imatinib and nilotinib on lipopolysaccharide-induced acute lung injury during neutropenia recovery in a mouse model
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P4634
VO 40
IS Suppl 56
A1 Sook Young Lee
A1 Chin Kook Rhee
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P4634.abstract
AB Objective: Neutropenia recovery is associated with deterioration in oxygenation and exacerbation of pre-existing pulmonary disease. We aimed to evaluate effect of imatinib and nilotinib on lipopolysaccharide (LPS) - induced acute lung injury (ALI) during neutropenia recovery in a mouse model.Method: We developed a mouse model of ALI during neutropenia recovery. Cyclophosphamide was administrated to induce neutropenia. During neutropenia recovery, ALI was induced by intratracheal instillation of LPS. Imatinib or nilotinib was administrated during neutropenia recovery.Result: The numbers of inflammatory cells and neutrophil in bronchoalveolar lavage fluid in imatinib or nilotinib group were significatly lower than LPS group. Imatinib or nilotinib administration significantly reduced wet/dry ratio and ALI score. The level of myeloperoxidase and tumor necrosis factor-α in imatinib or nilotinib group were significantly lower than LPS group. Attenuation of ALI by imatinib or nilotinib was associated with PDGFRβ and C-kit pathway.Consult: Imatinib or nilotinib effectively attenuated LPS-induced ALI during neutropenia recovery.