RT Journal Article
SR Electronic
T1 The evaluation of sensory gating with P50 paradigm in chronic obstructive pulmonary disease
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P216
VO 40
IS Suppl 56
A1 Ozden Kamisli
A1 Hilal Ermis
A1 Suat Kamisli
A1 Gazi Gulbas
A1 Cemal Ozcan
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P216.abstract
AB Objective: Chronic obstructive pulmonary disease (COPD) is a common preventable and treatable disease characterized by persistant airflow limitation in the airway. It is major cause of morbidity and mortality throughout the world. It is well known that COPD is associated with significant systemic abnormalities. Numerous neurological involvement like cerebrovascular diseases, motor neuron diseases and cognitive impairement has been reported in COPD. Cognitive dysfunction is usually associated with hypoxia or hypercarbia in these patients. We aimed to investigate the relationship between arterial blood gas analysis and pulmonary function test parameters with P50 sensory gating in COPD patients.Methods: 25 male (mean age 65.16 ± 9.95 years) patients with COPD and 17 healthy male controls (61.52 ± 6.33 years) were included into the study. The diagnosis of COPD was defined according to GOLD guidelines. P50 and N100 measurements were taken, the suppression percentage of P50 and N100 was calculated.Results: COPD patients showed significantly less P50 and N100 suppression when compared to healthy controls. P50 suppression percentage mean was 43.82 ± 30.23 in COPD patients, and 65.21 ± 15.77 in controls (p=0.012). N100 suppression percentage was 35.56± 28.95 in COPD patients and 55.63 ± 31.66 in controls (p=0.042).Conclusion: We found reduced P50 and N100 suppression in COPD patients. This impairment is more clear in hypoxic COPD patients. Hypoxia leads to a decrease in cerebral perfusion and an impairment of some cognitive abilities. P50 sensory gating may be considered as a marker for cognitive decline in COPD patients. To our knowledge, this is the first P50 sensory gating study in COPD.