PT - JOURNAL ARTICLE AU - Esther Helen Steveling AU - Caroline Newerla AU - Selina Dürr AU - Claudia Gerhards AU - Sabrina Maier AU - Christoph Stippich AU - Antje Welge-Lüssen AU - Stefanie Zogg AU - David Miedinger AU - Jörg Daniel Leuppi TI - Computed tomography of the paranasal sinuses in chronic obstructive pulmonary disease DP - 2012 Sep 01 TA - European Respiratory Journal PG - P3962 VI - 40 IP - Suppl 56 4099 - http://erj.ersjournals.com/content/40/Suppl_56/P3962.short 4100 - http://erj.ersjournals.com/content/40/Suppl_56/P3962.full SO - Eur Respir J2012 Sep 01; 40 AB - Background: Pathologic correlates of the upper airways have been rarely evaluated in chronic obstructive pulmonary disease (COPD).Aims: Assessment of objective and subjective impairment of the upper airways in COPDMethods: Computed tomography (CT) of the paranasal sinuses was performed in patients with COPD and evaluated using the Newman scoring system (>0 points considered abnormal). Nasal endoscopy was performed and scored according to Lund and Kennedy (>1 point considered abnormal). Rhinosinusitis related quality of life and symptoms were assessed with the Sino Nasal Outcome Test-20 (SNOT-20) (>12 points considered abnormal) and the SNOT-primary nasal symptoms score (SNOT-PNS). Spirometry was performed according to established guidelines. Patients were classified into COPD risk groups according to the GOLD guidelines of December 2011 considering symptoms, COPD stages 1-4 and exacerbations.Results: We included 83 patients (35 women) with a mean age of 68 years (range: 44-90). 29 subjects (35%) were in COPD risk group A, 38 subjects (46%) in risk group B and 16 subjects (19%) in risk groups C and D. Abnormal CT scores were observable in 49 subjects (59%) and abnormal endoscopies were found in 51 subjects (61%). 51 subjects (61%) scored abnormal results in the SNOT-20. We found a positive correlation between the CT score and the SNOT-PNS (r=.22, p<.05). The endoscopic score correlated positively with the SNOT-PNS (r=.29, p<.05) as well as with the SNOT-20 (r=.42, p<.01). Subjects in higher risk groups presented higher scores in endoscopy (p<.05), SNOT-PNS (p<.05) and SNOT-20 (p<.01).Conclusion: Pathologic correlates of the upper airways were found in more than half of the patients with COPD.