RT Journal Article
SR Electronic
T1 Improved results after preoperative concurrent chemotherapy and high dose radiation therapy in selected cases with stage III N2 lung cancer?
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2914
VO 40
IS Suppl 56
A1 Kalliopi Athanassiadi
A1 Evangelos Balis
A1 Nectarios Alevizopoulos
A1 Dimitris Lioumpas
A1 Maria-Kalliopi Konstantinidou
A1 Iakovos Ttofi
A1 Irini Mavromati
A1 Argini Psevdi
A1 Lucilla Comis
A1 Despina Violidaki
A1 Dimitra Rondogianni
A1 Ion Bellenis
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P2914.abstract
AB OBJECTIVE: Optimal management of stage IIIA-N2 non–small cell lung cancer remains controversial. The use of neoadjuvant chemoradiotherapy can present challenges in the perioperative management of patients undergoing lung resection for non-small cell lung cancer. Preoperative chemoradiotherapy may reduce pulmonary function, and can result in significant fibrosis around key anatomic structures, making dissection difficult and hazardous.METHODS: This is a retrospective study of 40 consecutive patients with T1-3 N2 M0 lung cancer who underwent induction chemoradiation before surgical intervention from January 2005 through December 2011. Induction chemotherapy consisted of cisplatin, and etoposide; and concurrent radiotherapy to a mean of 59.3 Gy. Lung resection was performed within 6 weeks of completion of chemoradiation.RESULTS: Twenty-five patients were submitted to pneumonectomy, simple or intrapericardial one, 10 to lobectomies and 5 either to segmentectomies or atypical resection. R0 resection was achieved in all cases. The overall operative mortality rate was 2.5% (one died in the lobectomy group). No important morbidity was noted and the overall hospital stay ranged from 7 to 14 days.CONCLUSION: Chemoradiation before pulmonary resection in carefully selected patients with surgically resectable stage IIIA (N2) non–small cell lung cancer can be performed with low mortality and morbidity and might lead to improved overall and disease-free survival.