@article {CelaniP1952, author = {Camilla Celani and Anna Maria Zicari and Valentina De Vittori and Annalisa di Coste and Tauland Melengu and Luciana Indinnimeo and Anna Rugiano and Marzia Duse}, title = {Changes in skin prick test reactivity over 7-14 years in a population of food allergy children and asthmatic symptoms}, volume = {40}, number = {Suppl 56}, elocation-id = {P1952}, year = {2012}, publisher = {European Respiratory Society}, abstract = {Background: Allergic disorders are an increasing health problem among children.Aim: to describe the prevalence of sensitization to common food and inhalant allergens at different ages and the association with asthmatic symptoms.Methods: 174 children with positive Skin Prick Test (SPT) to at least one food allergen at \<36 months were called after a follow-up period of 7-14 years to repeat SPT, to complete a questionnaire about asthmatic symptoms, and to perform spirometry.Results: 174 children complete the questionnaire: 25.8\% had wheezing, 34.4\% had dry cough and 35.6\% reported diagnosis of asthma. At the first observation 65 (37.3\%) had positive SPT only to food allergens(F) and 109 (62.6\%) had sensitization to food and inhalant allergens (F+I). At the second observation in the group with single sensitization to F 50\% lost sensitization, 10\% retained sensitization to food and developed sensitization to inhalants (F+I) and 40 \% showed sensitization only to inhalants. In the group with double sensitization (F+I) at the first observation: 50\% remained positive to both allergens (F+I), more than 40\% were positive only to inhalants and a small percentage (\<10\%) became negative. The sensitization profiles differed significantly between two groups (F and F+I). FEV 1 and FEF25-75 were significantly lower in the group F+I at the first observation than in the group F (p\<0.01).Conclusion: We found an association between changes in SPT positivity and the development of asthmatic symptoms. The double sensitization (F + I) as well as the early sensitization to alants would seem to correlate with the persistence of the allergy and with the development of respiratory disease.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/40/Suppl_56/P1952}, eprint = {https://erj.ersjournals.com/content/40/Suppl_56/P1952.full.pdf}, journal = {European Respiratory Journal} }