RT Journal Article
SR Electronic
T1 Saturated fatty acids in exhaled breath condensate in COPD patients
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2207
VO 40
IS Suppl 56
A1 T.N. Anokhina
A1 E.K. Anaev
A1 A.I. Revelsky
A1 I.A. Revelsky
A1 A.G. Chuchalin
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P2207.abstract
AB In recent years suggest that individual saturated fatty acid (SFA) has specific properties which are associated with important biological functions. The composition of SFAs in exhaled breath condensate (EBC) in COPD has not previously been studied.Aim: To identify SFAs in EBC and to assess their relationship with clinical and functional parameters in patients with COPD.Methods: We have studied 20 patients with COPD and 30 healthy nonsmokers. EBC was collected using ECoScreen. SFAs in EBC have been identified by gas-chromatography - mass-spectrometry method (GC-MS) and NIST-2005 library.Results: 12 SFAs (palmitic acid, stearic acid, myristic acid, etc.) have been identified in EBC in COPD patients. There were no differences in the content of SFAs in EBC in COPD patients and healthy subjects. We have found the relationship between EBC content of caproic acid (R=-0.46), enanthic acid (R=-0.61), caprylic acid (R=-0.50) and FVC in COPD patients (p<0.05). In addition, the content of myristic acid in EBC significant correlated with oxygen saturation (R=-0.45), breath frequency (R=0.48), pulmonary artery systolic pressure (R=0.73), MRS dyspnoea scale (R=0.52) and Paggiaro symptoms scale (R=0.58) in COPD patients.Conclusion: The content of different SFAs in EBC is associated with clinical symptoms and functional parameters in COPD patients reflecting their role in the inflammatory process in the lungs.